tert-butyl (3S,5S)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate
[(3S,5S)-5-(Hydroxymethyl)-3-pyrrolidinyl]carbamic acid tert-butyl ester
CAS: 663948-85-4
Molecular Formula: C10H20N2O3
tert-butyl (3S,5S)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate - Names and Identifiers
tert-butyl (3S,5S)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate - Physico-chemical Properties
| Molecular Formula | C10H20N2O3 |
| Molar Mass | 216.28 |
| Density | 1.11±0.1 g/cm3(Predicted) |
| Boling Point | 351.4±35.0 °C(Predicted) |
| pKa | 12.21±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.5 |
tert-butyl (3S,5S)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate - Introduction
[(3S,5S)-5-(Hydroxymethyl)-3-yrrolidinyl] carbamic acid tert-butyl ester is an organic compound commonly abbreviated as HMPA. The following is a description of the nature, use, formulation and safety information of HMPA:
Nature:
-Appearance: colorless liquid
-Molecular formula: C9H18N2O3
-Molecular weight: 202.25g/mol
-Solubility: Soluble in water and common organic solvents
Use:
-Chemical synthesis: HMPA is a commonly used solvent and reaction catalyst, which is widely used in organic synthesis and can promote some substitution, elimination, condensation and other reactions.
-Pigment solvent: HMPA can also be used as a solvent and dispersant for dyes and pigments.
-Pharmaceutical industry: HMPA can be used to prepare intermediates for some drugs.
Preparation Method:
HMPA can be prepared by the following steps:
1. obtaining a hydroxymethylated derivative of pyrrolidine: reacting pyrrolidine in the presence of sodium chloroformate to obtain a hydroxymethyl derivative of pyrrolidine.
2. Reaction with tert-butyl carbamate: The hydroxymethylated derivative of pyrrolidine reacts with tert-butyl carbamate under alkaline conditions to generate HMPA.
Safety Information:
HMPA is a relatively safe compound under normal use conditions, but the following matters still need to be paid attention:
-Irritating to the skin, direct contact with the skin should be avoided.
-Inhalation of high concentrations of HMPA may cause ocular and respiratory system irritation.
-Avoid inhalation or ingestion during use.
-Proper laboratory practices and personal protective measures should be followed, such as wearing gloves, goggles and protective clothing.
Nature:
-Appearance: colorless liquid
-Molecular formula: C9H18N2O3
-Molecular weight: 202.25g/mol
-Solubility: Soluble in water and common organic solvents
Use:
-Chemical synthesis: HMPA is a commonly used solvent and reaction catalyst, which is widely used in organic synthesis and can promote some substitution, elimination, condensation and other reactions.
-Pigment solvent: HMPA can also be used as a solvent and dispersant for dyes and pigments.
-Pharmaceutical industry: HMPA can be used to prepare intermediates for some drugs.
Preparation Method:
HMPA can be prepared by the following steps:
1. obtaining a hydroxymethylated derivative of pyrrolidine: reacting pyrrolidine in the presence of sodium chloroformate to obtain a hydroxymethyl derivative of pyrrolidine.
2. Reaction with tert-butyl carbamate: The hydroxymethylated derivative of pyrrolidine reacts with tert-butyl carbamate under alkaline conditions to generate HMPA.
Safety Information:
HMPA is a relatively safe compound under normal use conditions, but the following matters still need to be paid attention:
-Irritating to the skin, direct contact with the skin should be avoided.
-Inhalation of high concentrations of HMPA may cause ocular and respiratory system irritation.
-Avoid inhalation or ingestion during use.
-Proper laboratory practices and personal protective measures should be followed, such as wearing gloves, goggles and protective clothing.
Last Update：2024-04-09 19:05:51
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Product Name: tert-Butyl ((3S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl)carbamate Visit Supplier Webpage Request for quotation
CAS: 663948-85-4
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 663948-85-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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